Improving dialysis and Quality of Life
M3Nephron is dedicated to transforming haemodialysis care for over 4 million chronic kidney disease patients worldwide. Addressing the limitations of current in-hospital dialysis -such as moderate clinical outcomes, high costs, environmental impact, and poor patient quality of life- M3Nephron has developed advanced mixed matrix membranes.
These innovative membranes enhance toxin removal from blood, regenerate dialysate using lower-quality water, and support portable and wearable dialysis devices. By enabling efficient, flexible, and home-based treatments without the need for complex water purification, M3Nephron’s technology aims to improve patient outcomes, reduce healthcare costs, and minimize environmental impact, setting a new standard in dialysis therapy.
An increasing number of over 4 million patients suffering from Chronic Kidney Diseases (CKD) and are receiving Kidney Replacing Therapy1 (KRT). The increasing number of dialysis patients can be attributed to an aging population, as well as the rise in diabetes and hypertension rates. This surge has led to an increased pressure on dialysis capacity and healthcare costs.
Worldwide, 85% of End Stage Renal Disease (ESRD) patients are treated with haemodialysis (HD) despites only moderate clinical outcomes against high costs. The current applied filter technology in conventional HD leads to accumulation of uremic solutes which plays an important role in CDK related morbidity and mortality.
Suboptimal dialysis leads to poor outcomes and serious side effects such as high mortality rates, Cardiac fibrosis, Cardiac hypertrophy and Vascular calcification. In addition, HD therapy is an expensive therapy with serious environmental impact due to high water and energy consumption together with high waste production.
Reference 1. David Loureiro Ramada et al. Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges. nature reviews nephrology Vol 19. 202
Changing dialysis filtration, enabling dialysis and portable renal replacement therapies, improving patient Quality of Life
To address these challenges, there is a pressing need to enhance filtration technology in Haemodialysis (HD). By developing more efficient filters capable of continuous regeneration of a small volume of dialysate, we can significantly improve clinical outcomes for patients and reduce the carbon footprint supporting green dialysis. Furthermore, the miniaturization of dialysis equipment is crucial, enabling treatment at home or on the go, thus providing patients more flexibility, mobility and autonomy.
M3Nephron mixed matrixed membranes facilitate the development of new portable and wearable HD devices. These devices aim to better fit in patients daily life, offer improved dialysis, and address environmental challenges
