Improved dialysis, reduced dialysate, lower carbon footprint
An increasing demand in dialysis is to improve the efficacy, to reduce the treatment costs, reduce waste production and provide treatment at home or closer to home. Continuous KRT (for example, with use of portable artificial kidney and wearable artificial kidney devices) would more closely mimic the continuous nature of kidney filtration and might improve patient outcomes and enables greater patient mobility.
Most dialysis patients (75%) are treated in hospital with haemodialysis (HD). The operations of an In-Center Haemodialysis (ICHD) unit require high investment costs and resources while the treatment offers only moderate clinical outcomes. This is mainly caused due to the intermittent therapy of 3 times per week and the moderate performance of filters.
More continuous dialysis treatment at home or closer to home would address these challenges.
The performance of the filters is determined by a delicate balance between the capability of removal of toxins from the blood against the preservation of proteins in the blood together with the prevention of endotoxins entering the blood from the dialysate. The current applied filter technology has not been able fully meet these requirements leading to a suboptimal performance.
The implementation of mixed matrix membranes can address these requirements since it offers an improved clearance of urea toxins in blood while preserving albumins. Through clearance of endotoxins in the dialysate and its capability of dialysate regeneration the membranes are perfectly suited to be used in home settings avoiding the installation of water purification devices and simplifying home set-ups for patients and dialysis providers.
Mixed matrix membranes for simultaneous absorption and filtration
M3Nephron mixed matrix membranes can better remove protein bound uremic toxins from human blood with simultaneous removal of endotoxins from the dialysate through its absorption and filtration capabilities. The improved clearance of patient’s blood could lead to better clinical outcomes and improvement of patients’ quality of life.
M3Nephrons technology allows for regeneration of dialysate supporting lower dialysate volumes generated with low quality water. This could facilitate home haemodialysis without the need for Reverse Osmosis installation providing improved patient outcomes, and flexibility as well as water savings.
The M3Nephron dialyzer is perfectly suited to be applied in portable and wearable dialysis devices.
M3Nephron mixed matrix membranes can better remove protein bound uremic toxins from human blood with simultaneous removal of endotoxins from the dialysate through its absorption and filtration capabilities. The improved clearance of patient’s blood could lead to better clinical outcomes and improvement of patients’ quality of life.
M3Nephron’s technology allows for regeneration of dialysate supporting lower dialysate volumes generated with low quality water. This could facilitate home haemodialysis without the need for Reverse Osmosis installation providing improved patient outcomes, and flexibility as well as water savings.
The M3Nephron dialyzer is perfectly suited to be applied in portable and wearable dialysis devices.
